PRIMARY ANTIBODY

Anti-C5a-R/C5ar1 Antibody Picoband®

Mouse C5a Receptor 1 (C5AR1/CD88) Detection Antibody

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Product Description

Anti-C5a-R/C5ar1 Antibody Picoband® is an antibody designed to detect Complement Component 5a Receptor 1 (C5AR1), also known as C5a receptor or CD88. This receptor is a G protein-coupled receptor (GPCR) that binds the complement-derived inflammatory mediator C5a.

The antibody reacts with mouse samples and has been tested for ELISA, Flow Cytometry, Immunofluorescence (IF), Immunocytochemistry (ICC), and Western Blot (WB).

The Picoband® designation identifies a premium antibody selected for high affinity and strong signal performance with low background, particularly in Western blot applications.

Background: C5a Receptor 1 (C5AR1)

Complement Component 5a Receptor 1 (C5AR1), also known as CD88, is a G protein-coupled receptor involved in the complement system. It recognizes C5a, an anaphylatoxin generated during complement activation.

When C5a binds to C5AR1, the receptor activates intracellular signaling pathways that contribute to inflammatory and immune responses. C5AR1 is involved in the regulation of immune cell activity and inflammatory processes.

Research has also investigated the role of C5a receptor signaling in obesity, development, and cancer biology, making this receptor an important subject in immunology and disease-related research.

Key Features

• Target specificity: C5a receptor 1 (C5AR1/CD88)
• Reactivity with mouse samples
• Picoband® premium antibody designation
• Tested for ELISA and Flow Cytometry
• Tested for Immunofluorescence and Immunocytochemistry
• Tested for Western Blot
• Supplied as 100 µg per vial

Validated Research Applications

ELISA: Antibody-based detection and analysis of C5AR1 in appropriately prepared samples.

Flow Cytometry: Investigation of C5AR1 expression in cell populations using suitable staining protocols.

Immunofluorescence (IF): Visualization of C5AR1 in cells or tissue samples using fluorescence-based detection.

Immunocytochemistry (ICC): Examination of C5AR1 expression and localization in cultured cells.

Western Blot (WB): Detection and analysis of C5AR1 protein in biological samples.

Biological Significance of C5AR1

C5AR1 is an important component of complement-mediated signaling. Its interaction with C5a contributes to the recruitment and activation of immune cells and the regulation of inflammatory responses.

Studying C5AR1 expression can help researchers investigate:

• Complement system activation and signaling
• Inflammatory and immune responses
• G protein-coupled receptor signaling pathways
• Immune cell function and activation
• Complement-related mechanisms in cancer research
• Metabolic and developmental research involving C5AR1 signaling

Technical Specifications

Advance Your Complement System Research

Explore C5AR1 antibody detection for immunology, inflammation and cancer research.